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In its initial stage, these leukemias are asymptomatic in 60% of the cases are detected only after performing a routine laboratory, which is an increase in lymphocytes.

As the disease progresses, we see the presence of lymphadenopathy and organomegaly to increase as greater the number of lymphocytes.

You also have other symptoms caused by the decrease in the number of other blood cells such as red blood cells and platelets.

The anemia does not occur in the first stage of the disease, but when the bone is affected by the invasion of lymphocytes, there is a decrease of red blood cells. Anemia produces pallor, fatigue, shortness of breath and tachycardia.

Sometimes bleeding is shown by the decrease in platelets. They are serious when the platelet count is below 10,000 per ml and will not happen if the decline is not very intense (50,000 per ml).

It may not be reached to produce a large hemorrhage and that lack of platelets occurs only bruising, bleeding gums or nosebleeds mild.

Infections may occur because, although there are many lymphocytes, do not perform the tasks of defending properly. The typical cell chronic lymphocytic leukemia are reduced in size.

The alterations will determine the diagnosis:

The hemogram abnormalities consist of a lymphocytosis or increased numbers of lymphocytes per 000 ml 10000-100. 90% of these cells are small with scant cytoplasm and condensed chromatin.

The surface markers show a proliferation of B cells displaying a marker T.

Inmunoglubolinas expression on the cell surface is weak.
The most common biochemical change is the decrease of IgG for hypogammaglobulinemia.

In advanced stages, 50% of patients may have karyotype abnormalities.

For the diagnosis does not require an analysis of the bone marrow but it gives an idea of prognosis.

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